Measures of capacity predict individual differences in cognitive ability, including scholastic aptitude, intelligence, and aging-related cognitive change 1 and 2. Moreover, changes in working memory capacity accompany neurological and psychiatric disease [3] and may underlie behavioral Venetoclax research buy and cognitive deficits associated with these disorders [4]. However, just as the world is dynamic, so is the working memory system adapted

to address these dynamics. Thus, control processes are required in order to rapidly and selectively store information in memory (input control), to rapidly and selectively deploy subsets of that information for use in behavior (output control), and to selectively eliminate an obsolete representation from memory when its predicted utility declines (reallocation). Such control functions would seem to be crucial for strategically making use of capacity-limited working memory. And indeed, though less understood, individual differences in these control processes could be equally or even more important than the size of a static capacity for intellectual ability. Though still in its early stages, the last few years have yielded rapid advances in our understanding of how the brain solves the input, output, and allocation control problems facing working memory. These experiments have associated all three functions

with interactions between frontal and basal HSP phosphorylation ganglia systems. Below, we review this work to outline an account of how the brain manages working memory. There is a clear parallel between the problems addressed by working memory control processes ADP ribosylation factor and the fundamental

challenges faced by an animal’s motor system. Consider the task of hunting for dinner. For example, a predator must program motor actions on the basis of transiently observed information about prey (input control); maintain these programs until the time is right, enacting only the most appropriate motor program at that time (output control); and finally, refrain from perseveratively considering outdated motor programs, should the prey escape (reallocation; Figure 1a). Thus, demands on selective encoding, maintenance, utilization, and clearing of information face a variety of species. This similarity motivates the search for neural solutions that might also be shared across species. Indeed, recent phylogenetic analyses show that the basal ganglia (BG) has been highly conserved evolutionarily — all its major structures preserved since their debut in an unknown ancestor common to all vertebrates [5]. This conservation of structure may attest to the BG’s efficacy in solving the action selection problems faced by many species. One way to describe the dynamics of this selection function is as a gate that regulates the passage of information from one neural circuit to another [6], such as in the case of motor selection, between thalamus and motor cortex.