White-footed mice (Peromyscus leucopus) are an excellent species in which to investigate the effects of day length on adult hippocampal neurogenesis, as males, in addition to having reduced hippocampal volume in short days (SD) with concomitant impairments in hippocampus-mediated behaviors, have photoperiod-dependent changes in olfactory bulb neurogenesis. We performed the current experiment to assess the effects of photoperiod on hippocampal neurogenesis longitudinally,

using the thymidine analog bromodeoxyuridine at multiple time points across 10 weeks of SD exposure. Compared with counterparts held in long day (LD) lengths, across the first 8 weeks of SD exposure hippocampal neurogenesis was reduced. However, at 10 weeks in SD lengths neurogenic levels in the hippocampus were FDA approval PARP inhibitor elevated above those levels in mice held in LD lengths. The current findings are consistent with the natural photoperiodic cycle of hippocampal function in male white-footed mice, and may help to inform research on photoperiodic plasticity in neurogenesis

and provide insight into how the complex interplay among the environment, genes and adaptive responses to changing day lengths affects brain structure, function and behavior at multiple levels. “
“Magnetic resonance imaging has provided an increasing number of methods for examining the structure and function of the human brain. Among these, Diffusion CX-5461 supplier Metformin clinical trial Tensor Imaging (DTI), first described by Basser et al. (1994), has filled an important niche in structural brain imaging. By quantifying the diffusivity of water molecules within white matter tracts, investigators can obtain indices of their microstructural integrity. Most dramatically, by taking advantage

of the rotational invariance of DTI, researchers can perform tractography, i.e. constructing 3D models of the principal white matter tracts (Assaf & Pasternak, 2008). Despite the esthetic beauty of many such figures, the workhorse measures of DTI remain the voxel-wise indices of fractional anisotropy and mean diffusivity (White et al., 2008). In this current issue of EJN, Konrad et al. (2010) used DTI to examine white matter in a substantial sample (n = 37) of never-medicated adults with Attention-Deficit/Hyperactivity Disorder (ADHD). ADHD, which is characterized by behavioural symptoms of inattention, impulsivity and hyperactivity (American Psychiatric Association, 2000), is increasingly recognized as a disorder that affects individuals throughout the lifespan (Biederman et al., 2007). As expected (Casey et al., 2007; Makris et al., 2008), Konrad et al. (2010) found that patients with ADHD have reduced white matter fractional anisotropy in the right anterior cingulate bundle, and both reduced white matter fractional anisotropy and increased mean diffusivity in bilateral inferior frontoccipital fasciculus.