We also thank Du Qingyun and Qian Hongliang for the production of Mabs, Tanja Kiener for proofreading of the manuscript. We declare no competing interests. References 1. Fouchier RA, Munster V, Wallensten A, Bestebroer TM, Herfst S, Smith D, Rimmelzwaan GF, Olsen B, Osterhaus AD: Characterization of a novel PLX-4720 influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls. J Virol
2005,79(5):2814–2822.PubMedCrossRef 2. Thontiravong A, Payungporn S, Keawcharoen J, Chutinimitkul S, Wattanodorn S, Damrongwatanapokin S, Chaisingh A, Theamboonlers A, Poovorawan Y, Oraveerakul K: The single-step FDA approved Drug Library screening multiplex reverse transcription-polymerase chain reaction assay for detecting H5 and H7 avian influenza A viruses. Tohoku J Exp Med 2007,211(1):75–79.PubMedCrossRef 3. Apisarnthanarak A, Warren DK, Fraser VJ: Issues relevant to the adoption and modification of hospital infection-control recommendations for avian influenza (H5N1
infection) in developing countries. Clin Infect Dis 2007,45(10):1338–1342.PubMedCrossRef 4. Babakir-Mina M, Balestra E, Perno CF, Aquaro S: Influenza virus A (H5N1): BMS345541 nmr a pandemic risk? New Microbiol 2007,30(2):65–78.PubMed 5. Park AW, Glass K: Dynamic patterns of avian and human influenza in east and southeast Asia. Lancet Infect Dis 2007,7(8):543–548.PubMedCrossRef 6. Peiris JS, de Jong MD, Guan Y: Avian influenza virus (H5N1): a threat to human health. Clin Microbiol Rev 2007,20(2):243–267.PubMedCrossRef
7. Alexander DJ, Brown IH: History of highly pathogenic avian influenza. Rev Sci Tech 2009,28(1):19–38.PubMed 8. Organization. WH: Cumulative number of confirmed human cases of avian influenza A/(H5N1) reported to WHO. [http://www.who.int/csr/disease/avian_influenza/country/cases_table_2010_08_31/en/index.html] 2009. 9. Kaiser L, Briones MS, Hayden FG: Performance of virus isolation and Directigen Flu A to detect influenza A virus in experimental human infection. J Clin Virol 1999,14(3):191–197.PubMedCrossRef 10. Woo PC, Chiu SS, Seto WH, Peiris M: Cost-effectiveness of rapid diagnosis of viral respiratory tract infections in pediatric patients. J Clin Microbiol Erythromycin 1997,35(6):1579–1581.PubMed 11. Chen J, Jin M, Yu Z, Dan H, Zhang A, Song Y, Chen H: A latex agglutination test for the rapid detection of avian influenza virus subtype H5N1 and its clinical application. J Vet Diagn Invest 2007,19(2):155–160.PubMed 12. Wei HL, Bai GR, Mweene AS, Zhou YC, Cong YL, Pu J, Wang S, Kida H, Liu JH: Rapid detection of avian influenza virus a and subtype H5N1 by single step multiplex reverse transcription-polymerase chain reaction. Virus Genes 2006,32(3):261–267.PubMedCrossRef 13.