These lozenges have also been shown to be effective for the symptomatic OICR-9429 treatment of sore throat in children aged >5 years with acute and aggravated chronic pharyngitis [15]. A primary consideration for the development of a pediatric formulation is the acceptability to children [16]. Many investigators cite palatability as an important factor in medication adherence and completion of therapy in children, although formal studies are lacking [17].

Little direct evidence exists to show that poor palatability decreases adherence; however, it is not unreasonable to assume that a more palatable medication is easier to administer to infants and young children. Previous taste testing in children has shown that they generally prefer sweet preparations with fruit flavors [18]. National favorites are bubble gum and grape in the USA, citrus and red berries in Europe, and liquorice in Scandinavia [16]. The hedonic facial scale, which uses a pictorial scale of facial expressions, has been commonly employed in determining the acceptability of medications to children [18]. Compared with spontaneous verbal judgment, this method has the advantage of being more standardized. Studies

have shown that children aged as young as 4 years can understand and

use this scale to indicate whether a substance tastes pleasant and is therefore acceptable PARP inhibitor [18]. This scale Proteases inhibitor has previously been used to evaluate the acceptability of a wide range of medications among children, including steroid preparations [19], antibiotics [20–22], calcium and vitamin D3 [23, 24], ondansetron [25], and lansoprazole [26, 27]. The purpose of this study was to evaluate the acceptability of two licensed, commercially available throat lozenges containing AMC/DCBA, one strawberry and the other orange flavored, in healthy children aged 6–12 years, taken sequentially on the taste-testing day. Taste was assessed using the 7-point hedonic facial score, which was the primary measure of acceptability, as well as spontaneous reaction and verbal responses to questions AZD8931 nmr relating to palatability, flavor, and the feel of the lozenge in the mouth. 2 Methods 2.1 Study Design This was an open-label, single-dose, crossover, taste-testing study in children to investigate the acceptability of two different flavors of AMC/DCBA lozenges. It was conducted in accordance with the Declaration of Helsinki [28] and was reviewed by the Reading Independent Ethics Committee (Reading, Berkshire, UK). The International Standard Randomized Controlled Trial Number is ISRCTN34958871.