Conclusions: This is the first report to indicate a mosaic pregnancy after transfer of a “”euploid”" blastocyst that was screened by DNA microarray, and the case further confirms that mosaicism is present in human blastocysts produced by in vitro fertilization.”
“Two new furanocoumarins, lucidafuranocoumarins B (1) and C (2), were isolated from the twigs of Feroniella lucida, together with five known compounds (3-7). The structures of these compounds were identified on the basis of extensive spectroscopic methods.

The absolute configurations of lucidafuranocoumarin C at C-2 ” and C-5 ” were established as R-and S-configurations, respectively, by applying Mosher’s method. Some isolates were also evaluated for their cytotoxicity against KB, MCF-7 and NCI-H187 cell lines.

(C) 2012 Phytochemical Society of CAL101 Europe. Published by Elsevier B. V. All rights reserved.”
“This study consisted of the sediment toxicity assessment of the Bay of Cadiz based on two endpoints: growth inhibition for Cylindrotheca closterium (benthic microalgae) and fecundity inhibition for Tisbe battagliai (harpacticoid copepod). A new methodology to eliminate (but not as storage technique) the autochthonous biota LY3039478 chemical structure present in the sediment samples by immersing them in liquid nitrogen (-196 degrees C) was also assessed. Sediment toxicity data showed different toxicity levels for both organisms. In general, T battagliai was more sensitive; however a good correlation (r = 0.75; p < 0.05) between sediment toxicity results for both species was found. Data in pore water (pH, redox potential, and toxicity for microalgae and copepod) and sediment (pH, redox potential, organic carbon, and metal concentrations) demonstrated that ultra-freezing did not alter sample characteristics: thus, this technique can be adopted as a pre-treatment in whole-sediment toxicity tests in order to avoid misleading results

due to presence of autochthonous biota. Multivariate statistical analysis such as cluster and principal component analysis using chemical and ecotoxicological data were employed. Silt and organic matter percentage and lead concentration were found to be the factors that explain about 77% of sediment toxicity in the Bay of Cadiz. Assay methodology determined in this study for both assayed AZD7762 cost species is considered adequate to be used in sediment toxicity monitoring programs. Results obtained using both species show that the Bay of Cadiz can be considered a moderately polluted zone. (C) 2009 Elsevier Ltd. All rights reserved.”
“In this study, a novel poly(3-hydroxybutyrate-co-3-hydroxyoctanoate) (P(HB-HO)) microparticle with an encapsulated antibiotic (azithromycin, AZI) was prepared by the electrospinning method. The resulting microparticles were evaluated for surface morphology, particle size, drug loading, encapsulation efficiency, in vitro drug-release and degradation. The in vitro cytotoxicity and in vivo pharmacokinetics were also studied.