2 as a dissolution medium. At predetermined interval, the filtrate was analyzed by UV-spectrophotometer (λ = 335 nm). The loose and

tapped bulk densities of RAM, NIF and other excipients were determined by using a density apparatus (Serwell, India). The Compressibility index (CI %) and the Hausner’s ratio (HR) were calculated. Drug-excipients compatibility was carried out by FTIR spectroscopy and DSC. FTIR spectra of drugs and excipients were taken by using KBr pellet technique using a Shimadzu FT-IR spectrophotometer (Japan) in the wavelength region IOX1 order of 4000 to 400 cm−1. Thermal analysis of samples (drug or mixture of drug/s and excipients) were carried out using DSC (Perkin–Elmer, USA) method with a heating rate of 10 °C/min from 0 to 300 °C.7 The composition of the tablets is shown in Table 1. The core tablets containing RAM and HPMC in IPA (T1–T3) were prepared by granulation and later mixed with avicel. Magnesium stearate and Ac-Di-Sol were added to each blend and further mixed. The resultant blends were tableted to 80 mg using 10 stations Cadmach tablet press (India). Enteric

coating was given with Eudragit 10% solution using a Gans coater (India) and the coating solution was applied till 2% weight gain was achieved (tablet weight: 90 mg). All materials such as NIF-loaded microcapsules and excipients were passed through sieve no. 80. The outer tablets containing microcapsules of NIF, starch, SSG and avicel were prepared by granulation. Magnesium stearate and aerosil were added to each blend and further mixed. The resultant blends were tableted keeping Cell press the core tablet in between to 450 mg

Buparlisib (core: 90 mg + outer: 360 mg) using a 10 stations Cadmach tablet press. Thickness of tablets (n = 3) was determined using Vernier caliper (Mitutoyo, Japan). USP stated weight variation test of the tablets (n = 20) was carried out using electronic balance (Shimadzu, Japan). The hardness of tablets (n = 5) was tested using Monsanto hardness tester (Electrolab, USA). For each formulation, the friability of 6 tablets was determined using the Friabilator (Electrolab, USA). For determining the drug content of core tablets, 20 tablets (n = 3) were crushed and 100 mg of powder was dissolved in 100 ml of HCl buffer pH 1.2 for outer tablet and phosphate buffer pH 6.8 for core tablet respectively. These filtered solutions were analyzed by UV-spectrophotometer at 335 nm and 210 nm for NIF and RAM respectively. Disintegration tests were performed on tablets as per USP using disintegration apparatus (Electrolab, USA). To ensure the quality of core centration of tab-in-tab formulations, longitudinal and the transverse cuts were executed as shown in Fig. 1. Once several tablets have been cut which measured various displacement quantities.8 The in-vitro dissolution study was carried out using a USP Type II dissolution apparatus (Electrolab, USA) in 900 ml of SGF pH 1.2 for the first 2 h, followed by 900 ml of pH 6.