(c) 2013 Society of Chemical Industry”
“Study Design. Case report.
Objective. To report our results of a sacroplasty technique, using 3-dimensional C-arm CT for the treatment of sacral body fracture.
Summary of
Background Data. Sacroplasty may provide symptomatic relief and hasten recovery in the treatment of sacral insufficiency fractures. To our knowledge, there is no case report in the literature describing the application of sacroplasty for the treatment of sacral body fracture. We present a case of patient who had percutaneous sacroplasty for sacral body fracture and sacral alar fracture under 3-dimensional C-arm CT guidance and discuss the clinical results and technical considerations.
Methods. The procedure included a standard prone positioning of the patient and the area to be treated was prepared in a strictly sterile manner, and a local
anesthesia was used. After a small skin incision, an 11-gauge https://www.selleckchem.com/products/fosbretabulin-disodium-combretastatin-a-4-phosphate-disodium-ca4p-disodium.html vertebroplasty needle was positioned HSP990 solubility dmso at the entry point in the sacrum. Then, the needle was inclined, directed, and advanced from the posterior aspect to the anterior aspect of the sacral vertebral body. PMMA cement was incrementally introduced in 0.5 mL aliquots and the volume of PMMA cement injected was total 4 mL. Precise needle placement and PMMA cement injection was performed under the 3-dimensional C-arm CT system and the right sacral alar region was performed in a similar manner.
Results. There were no peri-procedural complications occurred and the patient experienced an immediate and substantial pain relief that was persistent during a 12-month follow-up.
Conclusions. 3-dimensional C-arm CT-guided sacroplasty is a safe, practical, and effective
solution to treatment of sacral body fracture.”
“Many anticancer drugs are obtained from phytochemicals and natural products. However, some phytochemicals have mutagenic effects. Safrole, a component of Piper betle inflorescence, 3-MA nmr has been reported to be a carcinogen. We have previously reported that safrole induced apoptosis in human oral cancer cells in vitro and inhibited the human oral tumor xenograft growth in vivo. Until now, there is no information addressing if safrole promotes immune responses in vivo. To evaluate whether safrole modulated immune function, BALB/c mice were intraperitoneally injected with murine myelomonocytic WEHI-3 leukemia cells to establish leukemia and then were treated with or without safrole at 4 and 16 mg/kg. Animals were sacrificed after 2 weeks post-treatment with safrole for examining the immune cell populations, phagocytosis of macrophages and the natural killer (NK) cells’ cytotoxicity. Results indicated that safrole increased the body weight, and decreased the weights of spleen and liver in leukemic mice. Furthermore, safrole promoted the activities of macrophages phagocytosis and NK cells’ cytotoxicity in leukemic mice when compared with untreated leukemic mice.