g., sensation testing) and multiple test findings (i.e., the number of positive
tests). The index tests were performed blinded to the MRI results. The diagnostic accuracy of the index tests in predicting herniations at the lower three lumbar discs was investigated using area under the curve (AUC), sensitivity and specificity.
Results. None of the individual Vorasidenib price neurological tests from the clinical examination were highly accurate for identifying the level of disc herniation (AUC > 0.75). The outcome of multiple test findings was slightly more accurate but did not produce high sensitivity and specificity. The dermatomal pain location was generally the most informative individual neurological test. The overall suspected level of disc herniation rated by the neurologist after a full examination of the patient was more accurate than individual tests. At L4/5 and L5/S1 herniations the AUC for neurologist ratings was 0.79 and 0.80 respectively.
Conclusion.
The current study did not find evidence to support the accuracy of individual tests from the neurological examination in identifying the level of disc herniation demonstrated on MRI. A neurologist’s overall impression was moderately accurate in identifying the level of disc herniation.”
“Background: Excessive gestational weight gain (GWG) increases the risk of a number of adverse pregnancy LY2606368 manufacturer GSK2245840 cell line outcomes and was recently identified as a potential risk factor for childhood obesity. It is therefore of interest whether GWG can be modified by an intervention combining dietary counseling and physical activity.
Objective: The objective was to review published data on interventions to reduce GWG by modulating diet and physical activity during pregnancy.
Design: We systematically reviewed 4 databases and bibliographies of various publications supplemented by a hand-search for relevant articles published in English or German and performed a meta-analysis to quantify the effect estimate by a random-effects model.
Results: Four
randomized controlled trials and 5 nonrandomized trials with a total of 1549 women enrolled were identified as being relevant. Meta-analyses of all 9 trials indicated a lower GWG in the intervention groups, with a standardized mean difference of -0.22 units (95% CI: -0.38, -0.05 units). We observed no indication for publication bias.
Conclusions: Interventions based on physical activity and dietary counseling, usually combined with supplementary weight monitoring, appear to be successful in reducing GWG. The results are of particular interest with respect to the objective of preventing excessive GWG. Am J Clin Nutr 2010;92:678-87.”
“The aim of this study was to evaluate the relationship of local intrarenal renin angiotensin system (RAS) with hypertension and proteinuria in renal transplant recipients.