In the Philippines, based on a study done in 2006, prevalence rates increased 4-fold over a 10-year period. It represents a spectrum of symptoms that vary from typical reflux symptoms of heartburn and regurgitation to dysphagia. It has also been considered a risk factor for esophageal cancer. GERD is generally a symptom-based diagnosis. Acid accounts for most of the irritation in GERD and Acid-suppressants, mainly proton pump inhibitors (PPIs) remain to be the mainstay of treatment. However, most PPIs have short half-lives and slow onset of action with gradual acid suppression owing to their pharmacologic

Temozolomide clinical trial properties. Peak acid suppression among all PPIs range from 6–11 days. In an Emergency room set-up, immediate relief from GERD symptoms is of paramount importance to suffering patients. This study aims to determine if an alginate (GAVISCON) is comparable to intravenous (IV) proton-pump inhibitor for the symptomatic relief of GERD symptoms. Methods: This is a prospective randomized open- labelled study conducted in Jose R. Reyes Memorial Medical Center Emergency Complex (Ambulatory

Division). Eligible subjects (N = 268) signed an PD0332991 datasheet informed consent to participate in the study iin which 2 groups were formed-Alginate group (N = 125) and the IV Omeprazole group (N = 143). 3 tests were used to analyze the results of this study:1. Kruskal-Wallis Test, 2.

Friedman Test and 3. Multiple Linear Regression and Multivariate Analysis of Variance. Results: Demographic data were similar in both groups. Majority of patients included in the study had moderate to severe symptoms of heartburn (141, 52.5%) and regurgitation (138, 51.5%). Using the parameter estimated changes to the pain rating scale given by each patient overtime after treatment, the data collated showed a significant difference on the onset of relief between the 2 groups. P values up to 3 hours were significant (p = 0.0000), while both groups had similar results at the 4th hour post-treatment. Conclusion: This study shows that alginates provide faster relief of see more GERD symptoms compared to IV Omeprazole. It is more practical as it is cheaper, especially when it comes to relieving GERD symptoms in an ER setting. Key Word(s): 1. GERD; 2. Alginates; 3. Omeprazole; Dependent Variable B p value Pain rating after 30 minutes −2.001 0.000 Pain rating after 1 hour −1.487 0.000 Pain rating after 2 hours −1.755 0.000 Pain rating after 3 hours −0.884 0.000 Pain rating after 4 hours 0.156 0.022 Presenting Author: ARUNKUMAR KRISHNAN Additional Authors: RAJESH PRABHU P, JAYANTHI VENKATARAMAN Corresponding Author: ARUNKUMAR KRISHNAN Objective: Long term acid suppressants are known to have adverse effects. s. Gastric acid secretion influences the density of H.