Mol Cell Biol 2008,28(17):5369–5380.PubMedCrossRef 16. Selaru FM, Olaru AV, Kan T, David S, Cheng Y, Mori Y, Yang J, Paun B, Jin Z, Agarwal R, Hamilton JP, Abraham J, Georgiades C, Alvarez H, Vivekanandan P, Yu W, Maitra A, Torbenson M, Thuluvath PJ, Gores GJ, LaRusso NF, Hruban R, Meltzer SJ: MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3. Hepatology 2009,49(5):1595–1601.PubMedCrossRef 17. Mylona E, Magkou C, Giannopoulou

I, Agrogiannis G, Markaki S, Keramopoulos A, Nakopoulou L: Expression of tissue inhibitor of matrix metalloproteinases (TIMP)-3 protein in invasive breast carcinoma: relation to tumor phenotype and clinical outcome. Breast Cancer Res 2006,8(5):R57.PubMedCrossRef 18. Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, Barbisin M, Xu NL, Mahuvakar Combretastatin A4 mouse VR, Andersen MR, Lao KQ, Livak KJ, Guegler KJ: Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005,33(20):e179.PubMedCrossRef 19. Yan LX, Huang XF, Shao Q, Huang MY, Deng L, Wu QL, Zeng YX, Shao JY: MicroRNA miR-21 overexpression in human

breast cancer find more is IKK inhibitor associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA 2008,14(11):2348–2360.PubMedCrossRef 20. Qian B, Katsaros D, Lu L, Preti M, Durando A, Arisio R, Mu L, Yu H: High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1. Breast Cancer Res Treat 2009,117(1):131–140.PubMedCrossRef 21. Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, Shimizu M, Rattan S, Bullrich F, Negrini M, Croce CM: Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004,101(9):2999–3004.PubMedCrossRef ADP ribosylation factor 22. Calin GA,

Croce CM: Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications. J Clin Invest 2007,117(8):2059–2066.PubMedCrossRef 23. Jiang Y, Goldberg ID, Shi YE: Complex roles of tissue inhibitors of metalloproteinases in cancer. Oncogene 2002,21(14):2245–2252.PubMedCrossRef 24. Helleman J, Jansen MP, Ruigrok-Ritstier K, van Staveren IL, Look MP, Meijer-van Gelder ME, Sieuwerts AM, Klijn JG, Sleijfer S, Foekens JA, Berns EM: Association of an extracellular matrix gene cluster with breast cancer prognosis and endocrine therapy response. Clin Cancer Res 2008,14(17):5555–5564.PubMedCrossRef 25. Bai YX, Yi JL, Li JF, Sui H: Clinicopathologic significance of BAG1 and TIMP3 expression in colon carcinoma. World J Gastroenterol 2007,13(28):3883–3885.PubMed 26.