The establishment of the degree of carotid stenosis by duplex US and angiography (magnetic resonance angiography – MRA, computed tomography angiography – CTA, digital subtraction angiography – DSA) is an important part of the indication of carotid reconstruction surgery in asymptomatic patients. Prophylactic carotid revascularization may be considered in highly selected asymptomatic patients if the degree of stenosis reaches at least 60%

by angiography and 70% by duplex US (Class IIb, Level of Evidence: B) [5] and [6]. Elective coronary artery bypass graft (CABG) surgery makes previous carotid duplex US reasonable in patients with the following conditions: Selleck ERK inhibitor older than 65 years, history of cigarette smoking, PAD, left main coronary stenosis, history of stroke, TIA or carotid bruit (Class IIa, Level of Evidence:

C). http://www.selleckchem.com/products/Dapagliflozin.html Among survivors of ischemic stroke or TIA after the immediate management further investigations should be performed to assess the cause and pathophysiology of the event. The possible origin of ischemic stroke includes intra- or extracranial-artery atherosclerotic infarction, cardiac embolism, small-vessel disease, hypercoagulable state, dissection, sickle cell disease or it can be an infarct of undetermined cause. As initial evaluation all patients with the symptoms of TIA or ischemic stroke should have non-invasive brain imaging (Class I, Level of Evidence: C). As a first step duplex US is recommended to detect carotid stenosis for patients with acute, focal neurological symptoms, which reflect the insufficient supply of certain brain territories from the left or heptaminol right ICA (Class I, Level of Evidence: C). If duplex US cannot be obtained or does not result in clear and diagnostic results, MRA or CTA is indicated as further imaging tools in the detection of carotid stenosis (Class I, Level

of Evidence: C). Correlation of findings detected by different non-invasive methods is very important in the aspect of quality assurance in every laboratory. When extra- or intracranial vascular alterations are found with such severity which cannot explain the neurological symptoms, further investigation should be performed to reveal the possible cardiac origin by means of echocardiography (Class I, Level of Evidence: C). Echocardiography serves as the gold standard in the examination of these patients. Detection of the source of cardiac embolism is of great importance regarding that this mechanism accounts for 15–30% of ischemic stroke or TIA [7] and [8]. Fig. 2 shows the diagnostic steps recommended in patients with symptoms of ischemic stroke or TIA.