These conclusions are in agreement with experimental results. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3532038]“
“This study was conducted to evaluate the relationship between the point Aa of the pelvic organ prolapse quantification (POP-Q) system and the Q-tip straining angle and to determine if Q-tip testing is required to assess urethral mobility.

A total of 250 women presenting with urinary incontinence were prospectively examined. Spearman’s correlation coefficient was used

to assess the degree of correlation between the POP-Q point Aa position and Q-tip values.

Urethral hypermobility was noted selleck screening library in 61% of stage I, 89% of stage II, and 100% of stages III and IV. A substantial negative correlation was found between the point Aa position and the straining Q-tip angle (r = 0.683, p < 0.0001).

A substantial correlation was found between descent at point Aa and the straining Q-tip angle. The point Aa of the POP-Q system is highly predictive of the abnormal straining urethral

angle in women with stage I or greater anterior vaginal wall prolapse.”
“Recombination between homologous, but non-allelic, stretches of DNA such as gene families, segmental duplications and repeat elements is an important source of mutation. In humans, recent studies have identified short DNA motifs that both BKM120 mouse determine the location of 40 per cent of meiotic cross-over hotspots and are significantly MS-275 cell line enriched at the breakpoints of recurrent nonallelic homologous recombination (NAHR) syndromes. Unexpectedly, the most highly penetrant form of the motif occurs on the background of an inactive repeat element family (THE1 elements) and the motif also has strong recombinogenic activity on currently active element families including Alu and LINE2 elements. Analysis of genetic variation among members of these repeat families indicates an

important role for NAHR in their evolution. Given the potential for double-strand breaks within repeat DNA to cause pathological rearrangement, the association between repeats and hotspots is surprising. Here we consider possible explanations for why selection acting against NAHR has not eliminated hotspots from repeat DNA including mechanistic constraints, possible benefits to repeat DNA from recruiting hotspots and rapid evolution of the recombination machinery. I suggest that rapid evolution of hotspot motifs may, surprisingly, tend to favour sequences present in repeat DNA and outline the data required to differentiate between hypotheses.”
“The effect of external electrical potentials (EEPs) on aqueous surfactant films nanoconfined in a ball-plate configuration has been investigated by measuring the dynamic film thickness with an interferometer.