They must also declare conflicts at each meeting of a WG. Any single conflict, real or apparent, may serve to disqualify a participant from participating in a WG. WG members may receive confidential and proprietary information from the FDA or others to assist SNS-032 purchase them in their discussions. When appropriate, they are therefore required to fulfill confidentiality requirements and, when required, sign non-disclosure forms prior to receiving such information. If, despite

all these safeguards, a conflict exists, limited waivers allow members to participate in committee discussions on condition that they are prohibited from voting on matters involving the specific or competing vaccine manufacturers. A member who develops an important conflict of interest during the 4-year term is required to resign from the ACIP. External consultants may participate despite conflicts of interest if they bring specific expertise, as long as their conflicts are declared and recorded at the Lumacaftor cell line beginning of each meeting. No special interest or lobbying groups provide any funding or any other

material support to ACIP or its members. Preparatory work for the in-person committee meetings involves two areas of ongoing activity. The ACIP WGs (currently numbering 14) meet regularly – at least once a month – to undertake an extensive, in-depth review of all relevant data and to prepare draft policy recommendations for consideration by the full ACIP in open meetings (see Section 8.1, below). The ACIP Secretariat is responsible for meeting preparations, which involves facilitation of WG proceedings; compilation of in-depth background technical background material that is published in a bound document distributed at least 2 weeks in advance of the meeting; and compilation of a Briefing Book, comprising concise (1–2 page) summaries of the key issues coming up for consideration or vote, which is distributed to the CDC Director, the ACIP membership and key Center/Division Directors at CDC. The Secretariat also is responsible for logistical preparations for each meeting, second i.e. meeting hall arrangements,

hard-copy handouts for the public, and audio-visual arrangements (including web-casting meetings in full, since July 2009). The Executive Secretary of ACIP, the Assistant to the Director for Immunization Policy and the ACIP Committee Management Specialist comprise the Secretariat, which was established in 2004 (prior to 2004 the work of ACIP was managed by the Executive Secretary alone). All three positions reside within CDC at the National Center for Immunization and Respiratory Diseases (NCIRD). Responsibility for reviewing and replying to inquiries from practitioners, members of the public, academics and others regarding the overall functioning of ACIP or about specific vaccine recommendations resides in the Secretariat as well.