This fullerene design may serve as a structural template from which a new set of potent compounds can be designed for the treatment of various diseases linked to sodium channel dysfunction. Acknowledgments We thank A. Robinson and R. Chen for their scientific advice. This work was supported by the NCI National Facility at the Australian National University. We gratefully acknowledge the support from the Australian Research Council through a Discovery Early Career Researcher Award and the National
Health and Medical Council. References 1. Norton RS: μ-Conotoxins selleck screening library as leads in the development of new analgesics. Molecules 2010, 15:2825–2844.CrossRef 2. Clark RJ, Akcan M, Kaas Q, Daly NL, Craik DJ: Cyclization of conotoxins to improve their biopharmaceutical properties. Toxicon 2012, 59:446–455.CrossRef 3. Dekan Z, Vetter I, Daly NL, Craik DJ, Lewis RJ, Alewood PF: α-Conotoxin Iml incorporating
stable cystathionine bridges www.selleckchem.com/products/wortmannin.html maintains full potency and identical three-dimensional structure. J Amer Chem Soc 2011, 133:15866–15869.CrossRef 4. Khoo KK, Wilson MJ, Smith BJ, Zhang MM, Gulyas J, Yoshikami D, Rivier learn more JE, Bulaj G, Norton RS: Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA. J Med Chem 2011, 54:7558–7566.CrossRef 5. Bakry R, Vallant RM, Najam-ul-Haq M, Rainer M, Szabo Z, Huck CW, Bonn GK: Medicinal applications of fullerenes. Int J Nanomed 2007, 2:639–649. 6. Da Ros T: Twenty years of promises: fullerene in medicinal chemistry. In Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes. Edited by: Cataldo F, Da Ros T. Netherlands: Springer
Science; 2008:1–21.CrossRef 7. Friedman SH, DeCamp DL, Sijbesma RP, Srdanov G, Wudl F, Kenyon GL: Inhibition of the HIV-1 protease by fullerene derivatives: model building studies and experimental verification. J Am Chem Soc 1993, 115:6506–6509.CrossRef 8. Prinzbach H, Weiler A, Landenberger P, Wahl F, Wörth J, Scott LT, Gelmont M, Olevano D, Issendorff B: Gas-phase production and photoelectron spectroscopy of the smallest fullerene, C 20 . Nature Celecoxib 2000, 407:60–63.CrossRef 9. Shinohara H, Sato H, Saito Y, Takayama M, Izuoka A, Sugawara T: Formation and extraction of very large all-carbon fullerenes. J Phys Chem 1991, 95:8449–8451.CrossRef 10. Park KH, Chhowalla M, Iqbal Z, Sesti F: Single-walled carbon nanotubes are a new class of ion channel blockers. J Biol Chem 2003, 278:50212–50216.CrossRef 11. Chhowalla M, Unalan HE, Wang Y, Iqbal Z, Park K, Sesti F: Irreversible blocking of ion channels using functionalized single-walled carbon nanotubes. Nanotechnology 2005, 16:2982–2986.CrossRef 12. Xu H, Bai J, Meng J, Hao W, Xu H, Cao JM: Multi-walled carbon nanotubes suppress potassium channel activities in PC12 cells. Nanotechnology 2009, 20:285102.