This study was funded by grants to JCL from the National Institutes of Health–National Center for Complementary and Alternative Z-VAD-FMK solubility dmso Medicine (K24-AT002422) and the Osteopathic Heritage Foundation. The authors thank the personnel at The Osteopathic Research Center for their contributions to this study. “
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image Download high-quality image (116 K) Download as PowerPoint slide Yukio Fukuyama (1928–2014) [Reproduced with modification from Brain Dev 2004;26:1–4 by permission.] Dr. Yukio Fukuyama, Professor Emeritus at Tokyo Women’s Medical University and the most respected child neurologist in the world, passed away in Tokyo on July 17, 2014, at age 86. He was born in a small town in Miyazaki Prefecture, Kyushu, and raised in Kumamoto City until the age of 20. He graduated from the Faculty of Medicine, The University of Tokyo, in 1952. During his medical school days, he became interested in neurology. Dr. Fukuyama was trained at the Department of Pediatrics after graduation and soon began promoting child neurology, which until then had not been well organized worldwide. He founded the Japanese Society of Child Neurology (JSCN) in 1961, the first child neurology society in the world, starting with about 150 members. Within 30 years this membership exceeded 3000. In fact,

the American Board of Psychiatry and Neurology awarded the first board certificate in Neurology Selleck LY294002 with Special Qualifications in Child Neurology in 1969, and

the Child Neurology Society was founded with an initial enrollment of 223 members three years later, in 1972. He was appointed Professor and Chairman of Pediatrics at Tokyo Women’s Medical College Galeterone (currently Tokyo Women’s Medical University) in 1967, and showed excellent leadership in the field of child neurology as well as in general pediatrics in Japan. He retired in 1994 and became Director at the Child Neurology Institute in Tokyo. He devoted himself to teaching, clinical practice, and scientific research for 27 years of his professorship. His memoir (Brain Dev 2004;26:1–4) described that he trained 330 physicians, guided 129 degree theses, and published 187 reviews and 661 original articles. His scientific interests and contributions covered broad areas in general pediatrics and child neurology, especially myology and epileptology. His most famous achievement was the discovery of Fukuyama congenital muscular dystrophy in 1960. Its causative gene was mapped at 9q31, which was later found to express the protein fukutin. These achievements were eventually awarded the Asahi Prize and several other domestic and international awards. He also pursued the study of myasthenia gravis in children, notably the seronegative type that is prevalent in Japan. He made a remarkable contribution also to pediatric epileptology.