17 Studies have shown that the majority of physicians in North America and Europe would consider withholding and Venetoclax mouse withdrawing treatment.6,7 There are still great differences between countries. Doctors in Holland and Belgium perform active euthanasia,18,19 whereas in Israel physicians withhold

but do not usually withdraw treatment.20 In fact the withdrawing of ventilators is prohibited by law.21 DIFFERENCES IN GEOGRAPHICAL LOCATION The Ethicus Study7 was a prospective trial performed in European ICUs to determine Inhibitors,research,lifescience,medical the frequency and types of actual end-of-life practices. European countries involved were prospectively divided into three geographical regions: Northern (Denmark, Finland, Ireland, the Netherlands, Sweden, and the United Kingdom), Central (Austria, Belgium, Czechia, Germany, and Switzerland), and Southern (Greece, Inhibitors,research,lifescience,medical Israel, Italy, Portugal, Spain, and Turkey) Europe. The main outcome variable was the end-of-life category (as defined above). In this study, 31,417 patients were admitted to 37 adult ICUs located in 17 countries over a period of 13.5 months. A total of 4,248 patients (13.5%) who died or had life-sustaining treatments limited in some fashion were included in the study. Limitation of life-sustaining Inhibitors,research,lifescience,medical treatment occurred in 3,086

of the 4,248 patients (73%), i.e. in 10% of ICU admissions and 76% of dying patients. Of the 3,086 patients, 2,734 (89%) received mechanical ventilation, and 1,815 (59%) were receiving vasopressors at the first limitation of therapy. There was significant inter-country variability in limitations of care. Twenty percent died with no limitation of therapy and unsuccessful

Inhibitors,research,lifescience,medical CPR (range 5%–48%), brain death in 8% (range 0%–15%), withholding treatment in 38% (range 16%–70%), withdrawing treatment in 33% (range 5%–69%), and active shortening of the dying process in 2% (range 0%–19%). Of 1,398 patients who underwent withdrawal of treatment, 1,335 (95%) had treatment withheld prior to or together with withdrawing treatment. All patients who underwent shortening Inhibitors,research,lifescience,medical of the dying process already had previous treatment withheld or withdrawn. This study highlights several important points. End-of-life decisions and actions are routine in European ICUs. Withholding and withdrawing treatment seem to be accepted by most European intensivists, while active shortening of the dying process was rare. The study provided useful not information for physicians and families regarding approximate times to death after various limitations. For example, death occurred a median of 3.5 (1.5–8.5) hours for shortening of the dying process, 4 (1.0–17.2) hours after withdrawing of therapy, and 14.3 (2.2–67.1) hours after withholding therapy.7 The study showed that respective probabilities of death within 24, 48, and 72 hours were 93%, 97%, and 99% for shortening of the dying process, 80%, 89%, and 93% for withdrawing, and 50%, 61%, and 68% for withholding treatments (Figure 2).7 Figure 2.