Closures are small square plastic clips with no outward sharp edges and widely used as bread Poziotinib datasheet bag clips. Once ingested, they present serious health hazard, even deadly. 36 cases, including the following, have been reported since 1975 from 5 countries (Canada 13, UK 9, USA 6, Australia 5, Japan 3). Methods: (Case) 66-years-old male presented to the emergency department after ingesting a bag closure. CT scan showed no significant findings. Upper GI endoscopy revealed the closure device lodged in the descending part of the duodenum, which had clutched the ulcerated mucosa between its teeth. The closure was endoscopically

removed with significant efforts and difficulty. Results: (Discussion) Among 36 cases (larynx 1, esophagus 2, stomach 2, duodenum 7, jejunum and ileum 20, colon 3, not specified 1), 10 endoscopic retrieval attempts yielded 6 successes, and 26 surgical operations revealed 11 perforations and resulted in 5 deaths. No preoperative X-rays/CT scans have ever pointed out an in-vivo Kwik Lok due to its radiolucency, however, three autopsies have discovered a closure. Reported are cases of intestinal obstruction, intestinal bleeding, ulceration and anemia. The longest period of incubation confirmed is 4 years. Conclusion: Kwik Lok™ Bag Closures should be recognized as a serious risk. If a patient find protocol presents after ingesting a Bag Closure, every possible measure should be employed to locate and retrieve the clip, or the patient

needs to be followed up for years, if not decades. Key Word(s): 1. Kwik Lok; 2. bag closure; 3. bread bag clip; 4. bread clip Presenting Author: SHUN ICHIRO OZAWA Additional Authors: MAEHATA TADATERU, SHINYA ISHIGOOKA, YOSHINORI SATO, YOSHIKO IKEDA, KOSUKE HOSOYA, YASUMASA MATSUO, MASAKI YAMASHITA, HIROYUKI YAMAMOTO, HIROSHI YASUDA, TAKASHI FUJINO, FUMIO ITOH Corresponding Author: SHUN-ICHIRO OZAWA Affiliations:

St. Marianna University School of Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, Meloxicam St. Marianna University School of Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine Objective: An 81-years-old woman presented to our hospital with positive fecal occult blood test result. Colonoscopy (CS) was performed and small polyp was detected at sigmoid colon. Follow-up CS was performed next year, and irregular flat depressed lesion 25 mm in diameter was detected at anal canal. Methods: Endoscopic biopsy suggested squamous cell carcinoma. The depressed lesion became clearer with the indigo carmine spraying image, but the margin of the anal side was still unclear. The lesion was depicted by the narrow band imaging (NBI) as brownish area.