1). The 80 trials (20 competitor, 20 unrelated, 40 filler) were arranged in a pseudo-randomized order that was fixed between participants. The pseudorandom order was designed such that targets appeared in each of the four quadrants an equal number of times and no image was seen more than once in three consecutive trials. Testing for the current study took place in two sessions: one for cognitive and

behavioral assessments Alectinib datasheet and one for the completion of the fMRI task. In the first session, participants gave informed consent on a protocol approved by a Human Subjects Committee. A trained experimenter administered cognitive measures and screened participants for claustrophobia, health conditions, and presence of metal in the body. Language proficiency was assessed using the picture vocabulary and passage comprehension sections of the Woodcock Language Proficiency Battery-Revised ( Woodcock, 1995) and the Woodcock-Muñoz Language Survey-Revised ( Woodcock, Muñoz-Sandoval, Ruef, & Alvarado, 2005).

Executive control was assessed using three measures derived from a colored squares version of the Simon Task ( Simon & Rudell, 1967): the Simon effect, the facilitation effect, and the inhibition effect. The Simon effect was calculated by subtracting mean reaction time on congruent trials from mean reaction time on incongruent BAY 73-4506 trials; the facilitation effect was calculated by subtracting mean reaction time on congruent trials from mean reaction time on neutral trials; and the inhibition effect was calculated by subtracting reaction times on neutral trials from mean reaction time on incongruent trials. Phonological working memory was measured using the digit span and non-word repetition subtests of the Comprehensive Test of Phonological Processing (CTOPP; Wagner, ID-8 Torgesen, & Rashotte, 1999). See Table 1 for group comparisons. On the day of scanning, participants were familiarized with the fMRI scanner and were given sound

dampening headphones to reduce scanner noise, a squeeze ball to signal the technician in case of emergency, and a button box to use to respond during the task. A four-image display was projected onto a mirrored screen, and participants received auditory instructions over the headphones to locate one of the four images. Each trial began with presentation of the visual search display. After 500 ms, participants heard an English auditory presentation of the target stimulus (recorded by a male professional voice actor2 at 48 kHz, amplitude-normalized). The search display remained on the screen for 2500 ms. Participants were instructed to indicate the target’s location using a button box with four buttons. Each response quadrant was assigned to a single response button (the top left button corresponded to the top left quadrant, the top right button to the top right quadrant, etc.). Stimuli were presented in an event-related design using E-Prime 2.