“
“Sequence alignments and SISCAN analyses inferred multiple interspecies recombination events within RNA2 of strains GHu of Grapevine fanleaf virus (GFLV) and Ta of Arabis mosaic virus (ArMV), two closely related subgroup A nepoviruses in the family Comoviridae. Interspecies recombination events MI-503 ic50 were identified in the 5′ untranslated region, the putative homing protein and movement protein genes but not in

the coat protein gene and 3′ untranslated region. These findings suggest a dynamic relationship between GFLV and ArMV, and a differential selection pressure on RNA2-encoded proteins with constraints in terms of function and co-adaptation that limit interspecies recombination to certain gene segments.”
“We compared the propensities of Enterococcus faecalis JH2-2 and of the recombination-deficient JH2-2 recA strain to develop mutational resistance to linezolid.

In both organisms, a mutation in a single rrl copy conferred resistance to linezolid. Delay in acquisition of the mutation by other rrl copies in JH2-2 recA showed that gene conversion contributed to the acquisition of resistance.”
“In the present study we aimed to investigate the effects of 2.1 GHz Wideband Code Division Multiple Access (W-CDMA) Galunisertib cost modulated Microwave (MW) Radiation on cell survival and apoptotic activity of human breast fibroblast cells. The cell cultures were exposed to W-CDMA modulated MW at 2.1 GHz at a SAR level of 0.607 W/kg for 4 and 24 h. The cell viability was assessed by MTT [3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] method. The percentage of apoptotic cells was analyzed by Annexin V-FITC and PI staining. 5,5′,6,6′-Tetrachloro-1,1′,3,3′- tetraethylbenzimidazolcarbocyanine iodide (JC-1) was used to measure Mitochondrial Membrane Potential (Delta I (m)). sFasL and Fas/APO-1 protein levels were determined by ELISA method. 2.1 GHz MW radiation was shown to be able to inhibit cell proliferation this website and induce apoptosis in human breast

fibroblast cells. The cell viability of MW-exposed cells was decreased significantly. The percentages of Annexin V-FITC positive cells were higher in MW groups. Delta I (m) was decreased significantly due to MW radiation exposure. However, neither sFas nor FasL level was significantly changed in MW-exposed fibroblast cells. The results of this study showed that 2.1 GHz W-CDMA modulated MW radiation-induced apoptotic cell death via the mitochondrial pathway.”
“Caudal regression syndrome (CRS) is a rare complex abnormality, characterized by agenesis of the sacrum and lumbar spine, with lower limb neurological deficit and accompanying deformities of the pelvis, lower extremities, genitourinary, gastrointestinal and cardiac systems. Pregnancies complicated by insulin treated diabetes carry higher risk of fetal CRS than non-diabetic pregnancies.

5 %) with a mean age of 71.2. 4 of these 10 patients had malignant tumors, the other 6 suffered from pulmonary embolism, pneumonia, stentgraft infection, CAD, Crohn’s disease and severe hypertension. The ratio of disease vs. radiation-related risk was between

2.1 : 1 and 1800: 1.\n\nConclusion: In this study referral for justified Xray procedures in a large hospital with high level medical care offers a significant patient benefit.”
“P>Title.\n\nEffect of supportive care on the anxiety of women with suspected breast cancer.\n\nAim.\n\nThis paper is a report of a study of the effect of supportive care on anxiety levels of women with suspected Rigosertib breast cancer during the diagnostic period.\n\nBackground.\n\nInformational and psychosocial support has been shown to improve care outcomes for women with breast cancer. However, little is known about the effect of supportive care on women’s psychological status during the breast cancer diagnostic period.\n\nMethods.\n\nFor this longitudinal quasi-experimental study, 122 participants were recruited from a large teaching hospital in Taiwan. The experimental group (n = 62) received a supportive care programme that included health education pamphlets about breast cancer diagnosis and treatment, three face-to-face sessions

of informational find more and emotional support, and two follow-up telephone consultations. The control group (n = 60) received routine care. Data were collected from October 2006 to April 2007 using the State-Trait Anxiety Inventory at baseline (notification of need for breast biopsy), before biopsy, and after receiving biopsy result (diagnosis).\n\nFindings.\n\nAfter

adjusting for covariance of breast discomfort, regular breast self-examination, and biopsy result, the anxiety levels of women receiving supportive care were significantly lower before biopsy (P = 0 center dot 017) and after diagnosis (P = 0 center dot 001) than those of women receiving routine care.\n\nConclusion.\n\nSupportive care that incorporates informational and emotional support and follow-up telephone consultations can decrease click here anxiety levels of women with suspected breast cancer. These findings can serve as a reference for clinical nursing staff to improve care quality during the breast cancer diagnostic period by providing women with individualized and culturally sensitive care.”
“P>Aim\n\nTo investigate the influence of the trajectory of NiTi rotary instruments on the outcome of cyclic fatigue tests.\n\nMethodology\n\nTen ProFile and Mtwo instruments tip size 20, taper 0.06 and tip size 25, taper 0.06 were tested in two simulated root canals with an angle of curvature of 60 degrees and radius of curvature of 5 mm but with different shape. Geometrical analysis of the angle and radius of the curvature that each instrument followed inside the two different artificial canals was performed on digital images.

Their fasting serum insulin, fasting glucose, insulin-like growth factor-1 (IGF-1) concentrations, and the homeostasis assessment model for insulin resistance (HOMA-IR) and beta-cell function (HOMA%) were evaluated. The values of HOMA-IR in CUG SGA were significantly higher than that in NCUG SGA (P=0.002) and AGA children (P=0.036), respectively. Correlation analysis revealed that the concentrations of fasting serum insulin were positively correlated with IGF-1 (r=0.443,

P=0.001) and Delta height standard deviation score (SDS; r=0.500, P=0.002) in <= 6-year- old SGA children, but only with Delta weight SDS (r=0.496, P=0.030) in >6-year-old children. In conclusion, SGA children with CUG in height and a higher body mass index are prone to the development of insulin resistance. Higher levels of insulin were closely correlated with the postnatal height CUG in young SGA children and with the weight CUG in old children.”
“Hospital surfaces play BEZ235 solubility dmso an Nepicastat important role in nosocomial infection (NI), in that the health-care environment contains a diverse population of microorganisms. Antibiotic resistance is the ability of a micro-organism to withstand the effects of an antibiotic, which is a specific type of drug resistance. Antibiotic resistance evolves naturally from a natural selection through random mutation, but could also be engineered by other selections. The research was performed

with laboratory method in Esfahan City and the SNS-032 purchase study as a whole comprised 194 strains obtained from hospital surfaces’ samples. These strains were randomly selected

from different wards of the hospital with sterile swab and NB medium. According to the results, Staphylococcus spp. (54.7%), Bacillus spp. (25%) and Enterobacteriaceae (10.7%) consist of isolated bacteria. The results of this study show high frequency of antibiotic resistant strain on hospital surfaces. Establishing systems for monitoring antimicrobial resistance in hospitals and the community, and linking these findings to resistance and disease surveillance data is fundamental to developing treatment guidelines accurately and to assessing the effectiveness of interventions appropriately.”
“In prescribing natural compounds, it is important matching scientific names of medicinal materials which I want to use and those which have been found those effects. This point is also important in Oriental medicine but isn’t kept because of differences in traditional sorting system and latest sorting system, external forms which are difficult to sort, and so on.. Baekbuja ((sic)) is a good example. In traditional Korean medicine, Aconitum koreanum Raymond (AKR) has been used as a Baekbuja, but in traditional Chinese medicine, Typhonium gigantum Engl. (TGE) has been used as a Baekbuja. Added to this, Helianthus tuberosis Linne (HTL) is used as an imitational Baekbuja in distribution channels and prescriptions now.

MmoS binds an FAD cofactor within its N-terminal tandem Per-Arnt-Sim (PAS) domains, suggesting that it functions as a redox sensor. The crystal structure of the MmoS tandem PAS domains, designated PAS-A and PAS-B, has been determined to 2.34 angstrom resolution. Both domains adopt the typical PAS domain alpha/beta topology and are structurally similar. The two domains are linked by a long alpha helix and do not interact with one another. The FAD cofactor is housed solely within PAS-A and is stabilized by an extended learn more hydrogen bonding network. The overall fold of PAS-A is similar to those of other

flavin-containing PAS domains, but homodimeric interactions in other structures are not observed in the MmoS sensor, which crystallized as a monomer. The structure both provides new insight into the architecture of tandem PAS domains and Suggests specific residues that may play a role

in MmoS FAD redox chemistry and subsequent signal transduction.”
“Objective: Exposure to cigarette Navitoclax Apoptosis inhibitor smoke in adult smokers (SM) can be determined by measuring urinary excretion of selected smoke constituents or metabolites. Complete 24h urine collections are difficult to achieve in ambulatory clinical studies; therefore spot urine (SU) might be a useful alternative. The objective of this study was to evaluate the optimum time for SU collections, and to predict 24h urine biomarker excretion from SU collections.\n\nMethods: SU samples were collected at three time points (early morning, post-lunch and evening) along with 24h collections in 37 healthy adult smokers. Nicotine and its five metabolites (nicotine equivalents, click here NE), metabolites of NNK (NNAL), pyrene (1-OHP), acrolein (HPMA), benzene (S-PMA) and butadiene (MHBMA) were measured in 24h and SU samples. Correlation and agreement between creatinine-adjusted SU and 24h urine collections were determined from the Pearson product-moment correlation, Bland-Altman and Lin’s concordance correlation

analyses. A random effect regression model was used to calculate the 24h biomarker excretion from SU collections.\n\nResults: There were no significant differences (p > 0.05) between the three SU collections for the selected biomarkers of exposure except for 3-HPMA, which showed a diurnal variation. Good correlation and statistical agreements were observed for creatinine-adjusted SU (all three time points) and 24h for most of the selected biomarkers. 24h biomarker excretion could be estimated for most of the biomarkers based on the regression model, with the early morning SU collections giving the best results for tobacco specific biomarkers NE (R-2 = 0.66) and NNAL (R-2 = 0.6).\n\nConclusions: SU is a useful alternative to 24h urine collections for most of the selected biomarkers of exposure to cigarette smoke.

A role for Sfrp1 in denervated muscle, other than interfering with canonical Wnt signaling, is discussed.”
“We analysed participants with type 2 diabetes (n=46) within a larger weight loss trial (n=146) who were randomized to 48weeks of a low-carbohydrate diet (LCD; n=22)

or a low-fat diet+orlistat (LFD+O; n=24). At baseline, mean body mass index (BMI) was 39.5kg/m(2) (s.d. 6.5) and haemoglobin A1c (HbA1c) 7.6% (s.d. 1.3). Although the interventions reduced BMI similarly (LCD -2.4kg/m(2); LFD+O -2.7kg/m(2), p=0.7), LCD led to a relative improvement in HbA1c: -0.7% in LCD versus +0.2% in LFD+O [difference -0.8%, 95% confidence interval (CI)=-1.6, -0.02; p=0.045]. LCD also led to a greater reduction in antiglycaemic medications using a novel medication effect score (MES) based on medication potency and total daily dose; 70.6% of LCD versus 30.4% LFD+O decreased their MES by 50% (p=0.01). Lowering dietary carbohydrate intake this website demonstrated benefits on glycaemic control beyond its weight loss effects, while at the same time lowering antiglycaemic

medication requirements.”
“A selective and sensitive fluorescence probe for hydrogen sulfide (H2S) detection was synthesized and evaluated in PBS buffer and fetal bovine serum. The effect of pH on the probe was also studied. In addition, visualization of H2S in Hela cells was achieved using confocal laser scanning Milciclib inhibitor fluorescence microscopy.”
“The paper presents description of new cantharid taxa from the inclusions in the Eocene Baltic amber: Hoffeinsensia jantarica gen. nov. and sp. nov., Sucinocantharis baltica gen. nov. and sp. nov., Malthinus danieli sp. nov., Malthodes sucinopenninus sp. nov. and Malthodes sucini sp. nov. The new genera are characterised by 12- or 16-segmented antennae.”
“The effects

of CO2 Ulixertinib order enrichment on the in vitro growth and acclimatization of Protea cynaroides L. plantlets were investigated. Three CO2 enrichment concentrations were used: 0 (control), 1000, 5000, and 10000 mu mol.mol(-1). Plantlets in the control treatment were cultured on half-strength Murashige and Skoog (MS) medium supplemented with sucrose, whereas those enriched with different CO2 concentrations were grown on sucrose-free MS medium. Compared with the control, significant improvements were observed in the growth of plantlets enriched with CO2 irrespective of the concentration. Plantlets enriched with 5000 mu mol.mol(-1) CO2 produced the highest number of leaves and the largest leaf area. In addition, the photosynthetic ability of plantlets enriched with CO2 was enhanced, which resulted in significant increases in shoot growth and dry matter accumulation. In particular, the shoot dry weight of plantlets cultured in 5000 mu mol.mol(-1) CO2 and 10000 mu mol.mol(-1) CO2 were, respectively, 2.1 and 4.2 times higher than those without CO2 enrichment.

In engineered tissues formed through self-assembly in a mold, artificially imposed boundary constraints have been found to induce anisotropic clustering of the cells and the extracellular matrix in local regions. To understand how such tissue remodeling at the intermediate length-scale (mesoscale) affects tissue stiffening, we used a novel microtissue mechanical testing system to manipulate C59 the remodeling of the tissue structures and to measure the subsequent changes in tissue stiffness. Microtissues were formed through cell driven self-assembly of collagen matrix in arrays of micro-patterned

wells, each containing two flexible micropillars that measured the microtissues’ contractile forces and elastic moduli via magnetic actuation. We manipulated tissue remodeling by inducing myofibroblast differentiation with TGF-beta 1, by varying the micropillar spring constants or by blocking cell contractility with blebbistatin and collagen cross-linking with BAPN. We showed that increased anisotropic compaction of the collagen matrix, caused by increased micropillar spring constant or elevated cell contraction force, contributed

to tissue stiffening. Conversely, collagen matrix and tissue stiffness were not affected by inhibition of cell-generated contraction forces. Together, these measurements showed that mesoscale tissue remodeling is an important middle step linking tissue compaction forces and tissue stiffening. (C) 2014 Elsevier Ltd. Selleck ZD1839 All rights reserved.”
“Background: This study aimed to explore the feasibility and effect of an intervention in clinical practice with isolated physical activity in individuals with IGT, recruited by the FINDRISC questionnaire. Methods: The questionnaire was sent to a population of 9734 individuals, 35-75 years old, in Sweden. Those DMH1 with a risk score bigger than = 15 were encouraged to perform an oral glucose tolerance test. Individuals with IGT were invited to participate in a randomized controlled trial with a focus on physical

activity. The participants were allocated to one of three arms; basic intervention, intensive intervention or to care as usual. A total of 52 individuals were carefully examined and questionnaires about diet and lifestyle were completed at baseline and after one year. All analyses were adjusted for differences in age and sex, and calorie intake when relevant. Results: The prevalence of chronic diseases in the study population was high, creating considerable difficulties in conducting a standardized test for fitness. Waist circumference (p=0.020), sagittal diameter (p=0.035), body weight (p=0.038) and BMI (p=0.043) decreased significantly more in the intensive care group than in care as usual and the basic care group. However, the significance was abolished when differences in energy intake were accounted for.

In the present study different cereal fibres (wheat, maize, oat and barley) were added at 3, 6 and 9 g/100 g level into a gluten-free bread Selleckchem EPZ5676 formulation based on corn starch, rice flour and hydroxypropyl methyl cellulose (HPMC). Doughs were evaluated based

on consistency, viscosity and thermal properties. Results showed that maize and oat fibre can be added to gluten-free bread with positive impact on bread nutritional and sensory properties. All breads with 9 g/100 g fibre increased the fibre content of control by 218%, but they were rated lower than those with 3 and 6 g/100 g fibre due to their powdery taste. The formulation containing barley fibre produced loaves that had more intense color and volume comparable to the control. During storage of breads a reduction in crumb moisture content and an

increase in firmness were observed. The micrographs of the crumb showed the continuous matrix between starch and maize and/or oat fibre obtaining a more aerated structure. (C) 2009 Elsevier Ltd. All rights reserved.”
“Diabetes mellitus type 2 in particular facilitates the manifestation of dyslipidemia, which in turn has a strong impact on the risk of diabetic patients to suffer from macrovascular or microvascular complications and also acute pancreatitis. This article describes the characteristics of diabetic dyslipidemia and discusses the diagnostic and prognostic value of classical and novel laboratory tests for further stratification. Moreover, the clinical and biochemical Crenolanib molecular weight presentation as well as primary and secondary causes of severe dyslipidemia are described.”
“In this work, the scintillation properties of Cs3LaCl6 and Cs3LaBr6 single crystals doped with various Ce concentrations (0.5 at.%-40 at.%) were studied. In the decay time profiles, both the fast (similar to 50 ns) and slow (similar to 500 ns) components decrease with increasing Ce concentration. The fast decay component dominates with high Ce concentration. Cs3LaCl6:Ce has a light yield of similar to 20 000 photons/MeV for 20 at.% Ce, while Cs3LaBr6:Ce

has a light yield of 35 000 photons/MeV click here for 10% Ce. Energy resolution was improved from 20 at.% to 8 at.% with higher Ce concentration. Cs3LaCl6:Ce and Cs3LaBr6:Ce are 30 and 8 times less hygroscopic than LaBr3:Ce.”
“The most common form of newborn chronic lung disease, bronchopulmonary dysplasia (BPD), is thought to be caused by oxidative disruption of lung morphogenesis, which results in decreased pulmonary vasculature and alveolar simplification. Although cellular redox status is known to regulate cellular proliferation and differentiation, redox-sensitive pathways associated with these processes in developing pulmonary epithelium are unknown. Redox-sensitive pathways are commonly regulated by cysteine thiol modifications. Therefore two thiol oxidoreductase systems, thioredoxin and glutathione, were chosen to elucidate the roles of these pathways on cell death.

\n\nIsolation among remnant, or newly created wetlands and ponds, and their consequent density in the landscape, is a key factor that can influence a variety of food web processes, including effects on mosquitoes which are important prey to many predators.\n\nWe assess the impact of habitat isolation on the density of pond-breeding mosquitoes (several Anopheles and Culex species) both directly and indirectly through the food web.\n\nResults from structural equation modelling of survey data shows that larval mosquitoes are denser in ponds that are more isolated from one selleck inhibitor another, and that this result was primarily driven indirectly by

a reduction of larval mosquito Nutlin-3 cost predators (e.g. predaceous insects and amphibians). Furthermore, results from a long-term mesocosm experiment factorially manipulating isolation and predator reduction

show that the effect of isolation on mosquito density was eliminated when predators were experimentally reduced.\n\nIt is concluded that metacommunity processes, both directly and indirectly mediated through predators, can play an important role in the local abundance of wetland breeding mosquitoes and possibly the diseases they spread.”
“Background: We recently reported a grading system for surgical complications. This system proved to have a high sensitivity for recording minor but meaningful complications prolonging hospital stay in patients after colorectal surgery. We aimed to prospectively validate the complication grading system MX69 in vitro in a general surgery department over 1 year. Methods: All surgical procedures and related complications were prospectively recorded between January 1st and December 31st, 2009. Surgical complications were graded on a severity scale of 1-5. The system classifies short- term outcome by grade emphasizing intensity of therapy required for treatment of the defined

complication. Results: During the study period, 2114 patients underwent surgery. Elective and oncological surgeries were performed in 1606 (76%) and 465 (22%) patients, respectively. There were 422 surgical complications in 304 (14%) patients (Grade 1/2: 203 [67%]; Grade 3/4: 90 [29%]; Grade 5: 11 [4%]). Median length of stay correlated significantly with complication severity: 2.3 d for no complication, 6.2 and 11.8 d for Grades 1/2 and 3/4, respectively (P smaller than 0.001). Older age (OR 2.75, P smaller than 0.001), comorbidities (OR 1.44, P = 0.02), American Society of Anesthesiology score bigger than 2 (OR 2.07, P smaller than 0.001), contamination Grade (OR 1.85, P = 0.001), oncological (OR 2.82, P smaller than 0.001), open (OR 1.22, P = 0.03), prolonged bigger than 120 min (OR 2.08, P smaller than 0.001), and emergency surgery (OR 1.42, P = 0.02) independently predicted postoperative complications.

A series of simulations are carried out to evaluate the accuracy of dataset acquired from the dynamic sampling mode. Reconstruction with the corresponding data obtained in the dynamic-mode process is also performed with the phantom.

The results demonstrate the feasibility of such an imaging mode when the angular velocity is set to the appropriate value, thus laying the foundation for real experiments to verify the superiority in performance of this new imaging mode over the traditional one.”
“Background: The occurrence of Giardia duodenalis in cats is of potential significance from both clinical and public health perspectives. The object of this Z VAD FMK study was antigenic detection of G. duodenalis in household cats of Ahvaz district, South-West of Iran.\n\nMethods: The prevalence of G. duodenalis was determined in fecal samples by two techniques: centrifugation-flotation and a commercial Giardia Antigen Test Kit (immunochromatography assay) in 150 household cats of different ages among referred cases to Veterinary Hospital of Ahvaz University from January 2008 to February 2010.\n\nResults: Five out of 150 fecal samples (3.33%) were positive for antigen of G. duodenalis by immunochromatography assay. The prevalence was significantly higher in young cats less than Cyclosporin A research buy 6 months (15.79%) compared with adult cats 6 months – 3 years (1.37%) (P=0.027) and above 3 years (1.72%) (P=0.044).

The infection had more prevalence in diarrheic cats (17.39%) compared with non-diarrheic IPI-145 price cats (0.79%) and the difference was significant (P=0.02) as well. The prevalence was higher in male cats (3.41%) than females (3.23%) and in the season of autumn (6.06%), but the difference was not significant between the prevalence of infection relative to host gender and season (P>0.05). Microscopy examination on fecal samples showed that 2% of the studied cats were positive.\n\nConclusion: The parasite antigen was present as a zoonotic infection in Ahvaz district, South-west of Iran. More sensitive techniques, such as immunochromatography assay, might yield more reliable results, in the detection of low levels of Giardia in fecal samples of cats.”
“Background/AIMS:

To investigate the meta-analysis of randomized controlled trials(RCTs) of the efficacy and safety between radiofrequency ablation (RFA) and surgical resection (SR) in treating small hepatocellular carcinoma (SHCC).Methodology: RCTs comparing RFA with SR for SHCC were collected from PubMed/Medline, Cochrane Library, EMBASE and CNKI data base. Odds ratios and 95% confidence intervals were calculated. Results: Five RCTs with a total of 776 patients were included in this analysis. The 1-, 3-year overall survival rate and 1-year recurrence-free survival rate were of no difference between the RFA and SR. However, SR was shown to be superior to the RFA with the analysis of 5-year overall rate and 3-, 5-year recurrence-free survival rate. The 1-year recurrence rate was similar between the SR and RFA.

The carboxyl group-functionalized polystyrene microspheres prepared by soap-free emulsion polymerization were used as the templates. The self-assembled PS microspheres were prepared via electrostatic attraction between PS and carboxyl group-functionalized polystyrene. The single-layer PS was self-assembled and subsequently crosslinked with glutaraldehyde (GA). Then, the PS hollow microspheres (PSHMs) were obtained after the templates were removed. It was found that the pH of the external environment played an important role on the particle size of the CX-6258 in vitro PSHMs. To estimate the feasibility as novel carriers, an antitumor model drug

5 fluorouracil (5 Fu) and gold nanoclusters (Au NCs) were incorporated into hollow microspheres. The antitumor activity of the 5Fu/Au NCs-loaded PSHMs against cancer HepG2 was evaluated by measuring the body weight change and tumor volume of tumor bearing mice. The gold nanoclusters kept their fluorescent stability during the whole study. The 5 Fu/Au NCs-loaded PSHMs showed comparable anticancer efficacy with the free drug. (c) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013″
“Purpose: The aim was to evaluate the utility of multiple blood-protein biomarkers for early-response assessment of radiation exposure using a murine radiation model system.\n\nMaterial and methods: BALB/c male

mice (8-10 weeks GDC-0994 concentration old) were exposed to whole-body (60)Co gamma-rays (10 cGy min(-1)) over a broad dose range (0-7 Gy). Blood protein biomarkers (i.e., Growth Arrest and DNA Damage Inducible Gene 45 or GADD45 alpha, interleukin 6 or IL-6, and serum amyloid A or SAA) were measured by enzyme linked immunosorbent assay (ELISA) at 4, 24, 48, and 72 h after total-body irradiation (TBI).\n\nResults: Time-and dose-dependent increases in the protein targets were observed. The use of multiple protein targets was evaluated using multiple linear regression analysis to provide dose-response calibration Fer-1 in vivo curves for dose assessment. Multivariate discriminant analysis demonstrated enhanced dose-dependent separation of irradiated animals from control as the number of biomarkers increased.\n\nConclusions: Results

from this study represent a proof-of-concept for multiple blood-proteins biodosimetry approach. It was demonstrated for the first time that protein expression profile could be developed not only to assess radiation exposure in male BALB/c mice but also to distinguish the level of radiation exposure, ranging from 1-7 Gy.”
“Uterine agenesis is one of the differential diagnoses in adolescent girls with delayed menstruation. It may also be suspected earlier in childhood during investigations for other genitourinary conditions. However, accurate confirmation that the uterus is absent can be extremely difficult before puberty because of its small size. We describe ten girls referred to a specialist centre with a presumed diagnosis of an absent uterus which was later found to be incorrect.